|
KMID : 0361120100240020087
|
|
Korean Journal of Transplantation
2010 Volume.24 No. 2 p.87 ~ p.92
|
|
|
Clinical Characteristics of Focal Segmental Glomerulosclerosis Recurrence after Adult Renal Transplantation
|
|
Joo Dong-Jin
Kim Myoung-Soo
Kim Soon-Il
Kim Yu-Seun
Lee Jung-Jun
Kim Soo-Jin
Huh Kyu-Ha
Lee Byung-Mo
|
|
|
Abstract
|
|
|
Background: Recurrence of focal segmental glomerulosclerosis (FSGS) after kidney transplantation is a frequent and still unpredictable complication. Moreover, risk factors for recurrence have not yet been clearly identified.
Methods: We enrolled into our study 2,882 adult kidney recipients who underwent transplantation between April 1979 and April 2009. We retrospectively reviewed clinical manifestations of recurrence of FSGS.
Results: Among the 2,784 adult renal recipients, forty four had undergone renal transplantation for primary FSGS. Of the 44, 12 (27.3%) showed recurrent FSGS. Mean duration between transplantation and FSGS recurrence was 22.8±37.4 months. There were no significant differences in patient characteristics in the recurrence and non-recurrence groups. The cumulative incidence of FSGS recurrence was 13.8% within 1 year after kidney transplantation and 23.2% within 3 years. The overall graft survival rate in the recurrence group was significantly lower than that of the non-recurrence group =0.0018) and non-FSGS group (P=0.0001). Graft failure happened more in the recurrence group (75%) than in the non-recurrence group (37.5%, P =0.042).
Conclusions: We failed to find any significant risk factors for FSGS recurrence after renal transplantation.
|
|
|
KEYWORD
|
|
|
Focal segmental glomerulosclerosis, Kidney transplantation, Risk factors, Recurrence
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|